smgGDS-607 Monoclonal Antibody

SmgGDS is a chaperone protein and guanine nucleotide exchange factor encoded by RAP1GDS1 that regulates the prenylation and trafficking of small GTPases and has a role in oncogenesis.{54803,59352,54804} Alternative splicing of the RAP1GDS1 pre-mRNA produces a full-length isoform, smgGDS-607, and a short isoform, smgGDS-558.{54803} SmgGDS-607 is composed of 607 residues and contains an N-terminal nuclear export sequence and multiple armadillo repeats, which are essential for binding to small GTPases that contain a C-terminal polybasic region.{54803,59352,54805} It is expressed in a variety of tissues and cancer cell lines.{59352} SmgGDS-607 binds to newly synthesized, preprenylated small GTPases and traffics them to prenyltransferases (PTases), which catalyze their prenylation, a process that is critical for the membrane localization and subsequent activation of small GTPases.{59352,54804} An elevated ratio of smgGDS-607 to smgGDS-558 has been observed in cancer cell lines and is associated with reduced survival in patients with breast cancer.{59352} Cayman's smgGDS-607 Monoclonal Antibody can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes a unique region of smgGDS-607 that is not present in smgGDS-558, specifically detecting smgGDS-607 at ~60 kDa from human and African green monkey samples.