Ganglioside GM1 Asialo Polyclonal Antibody

Ganglioside GM1 asialo (Item No. 15586) is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 (Item No. 19579) by neuraminidase.{25489,37774} Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody.{25488} The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in the lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals.{25489} Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-? levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 Asialo Polyclonal Antibody can be used for ELISA and TLC immunoblotting. [Matreya, LLC. Catalog No. 1950]