Paquinimod

Paquinimod is an immunomodulator.{52191,52192,52193,52194} In vivo, paquinimod reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of experimental autoimmune encephalomyelitis (EAE).{52191} Paquinimod (25 mg/kg per day) reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis.{52192} It delays disease onset and decreases insulitis in non-obese diabetic (NOD) mice.{52193} Paquinimod (5 and 25 mg/kg) reduces skin thickness, the number of myofibroblasts, and autoantibody production in the tight skin 1 mouse model of systemic sclerosis.{52194}