(-)-MK-801 (maleate)

(-)-MK-801 is an NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding) and an isomer of (+)-MK-801 (Item No. 10009019).{26258} In vivo, (-)-MK-801 blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg) and increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg).{45209} (-)-MK-801 (0.1 mg/kg) decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress, indicating antidepressant-like activity.{45210} (-)-MK-801 also inhibits acetylcholinesterase (AChE) with Ki values of 6.2 and 7.9 ?M for electric eel and rat brain AChE, respectively.{45211}