8-hydroxy DPAT (hydrobromide)

8-Hydroxy DPAT (8-OH-DPAT) is an agonist of serotonin (5-HT) receptor subtype 5-HT1A (EC50 = 12 nM in rat hippocampal membranes).{40744} It mimics the effect of serotonin (Item No. 14332) on reducing excitatory post-synaptic potentials (EPSPs) in the entorhinal cortex layers II and III when used at concentrations of 10 and 50 µM.{40748} In rhesus monkeys, it enhances the behavioral effects of d9-tetrahydrocannabinol (d9-THC; Item Nos. 12068 | ISO60157) in a discriminant stimulus-shock test when administered at a dose of 0.178 mg/kg.{40743} In mice, 8-OH-DPAT reduces the number of attack bites when administered directly to the dorsal raphe nucleus in a baclofen-induced model of aggressiveness and impairs contextual fear when administered prior to training at a dose of 0.5 mg/kg.{40747,40746} It also reduces the incidence of apnea and improves respiratory regularity in a methyl-CpG-binding protein 2-deficient mouse model of Rett syndrome when administered at a dose of 50 µg/kg.{40742} In a rat model of diabetes, 8-OH-DPAT enhances bradycardia in response to vagal electrical stimulation.{40745}