4'-O-methyl Quercetin

4'-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity.{39035,39036,39037} 4'-O-methyl Quercetin is a major metabolite of quercetin (Item No.10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 ?M.{39035} It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4'-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.{39036} 4'-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 ?M) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).{39037}