(-)-Ropivacaine (hydrochloride hydrate)

(–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers.{33665} In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 ?L of an 8 mM solution is injected percutaneously into the sciatic nerve.{42580} (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine (Item No. 16618).{42581} Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth.