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Polyclonal antibody to SMAC/Diablo
20-1089
50 ul
€358
Product description
Smac/DIABLO (second mitochondrial-derived activator of caspase/direct IAP binding protein with low pI) is encoded by the nucleus and resides as a precursor within the intermembranous space of the mitochondria. During apoptosis, Smac/DIABLO is proteolytically cleaved and released from the mitochondria into the cytosol, where it promotes cell death by interacting with IAPs and inhibiting their anti-apoptotic function. In turn, certain IAPs may degrade Smac/DIABLO and block its cell death function. Smac/DIABLO is expressed in a wide range of normal tissues and some tumor cells lines, and its over-expression in tumor cell lines can trigger both extrinsic and intrinsic apoptosis pathways.
Specifications
Applications
IP, IHC, WB
Host
Rabbit
Clonality
Polyclonal
Isotype
Rabbit IgG
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C
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Polyclonal antibody to SMAC/Diablo
20-1089
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Polyclonal antibody to SMAC/Diablo
20-1089
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