6-Methylsulfinylhexyl isothiocyanate

6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson's disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}