(E,Z)-2-propyl-2-Pentenoic Acid
(E,Z)-2-propyl-2-Pentenoic acid is an active metabolite of the anticonvulsant valproic acid (Item Nos. 35739 | 13033).{66494} It is an inhibitor of histone deacetylases (HDACs; IC50 = 2.8 mM). (E,Z)-2-propyl-2-Pentenoic acid is also an inhibitor of GABA aminotransferase (GABA-T) and Gsst (Kis = 0.5 and 4 mM, respectively, for the rat enzymes).{66495} It enhances acquisition of the conditioned avoidance response in mice when administered at a dose of 6 mg/kg.{66496}
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