N6-Methyladenosine Polyclonal Antibody

N6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in the messenger RNAs (mRNAs) of most eukaryotes and has been linked to effects on mRNA fate. The process shares similarities to histone methylation in that the modification is installed by m6A methylation “writers”, detected by methylation-specific “readers”, and can be reversed by demethylation “erasers”. The m6A modification has been found to be highly conserved around stop codons, in 3’-untranslated region, and within long external exons in both human and mouse cells.{25677} The process of regulating m6A modifications in mammalian mRNA has been linked to disease, where fat mass and obesity-associated (FTO) has been reported to be an obesity risk gene.{25677} FTO is an m6A demethylase and polymorphisms that result in increased FTO expression are associated with increased body mass and risk of obesity. Cayman’s N6-Methyladenosine Polyclonal Antibody can be used for ELISA and Southwestern dot blot applications.