15(R)-Prostaglandin F2a
15(R)-Prostaglandin F2? (15(R)-PGF2?) is the C-15 epimer of the naturally occurring mammalian autacoid PGF2?. It has only 25% of the potency of PGF2? in hamster antifertility studies, which may be due to reduced affinity for FP receptors.{1925} Compared to PGF2?, 15(R)-PGF2? has a binding affinity of 6.7% to ovine luteal cell receptors.{2058} Similarly, the binding affinity to rat vascular smooth muscle cells is negligible as compared to PGF2?.{2057}
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