The antibody recognizes a 40 kD protein(e.g. in nuclear extracts of human H345 cells), identified as thyroid transcription factor 1 (TTF-1), selectively expressed in the lung, thyroid and diencephalon. The antigen has been localized in the nucleus.
Tumors specifically detected: The antibody is useful in the classification of thyroid and lung tumors.
Positive control: Normal thyroid or lung.