Guanylate Cyclase B1 subunit (soluble) Polyclonal Antibody

Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein and nitric oxide (NO) sensor composed of two subunits, ?1 and ?1.{59045,59046} The approximately 70 kDa sGC ?1 subunit is encoded by GUCY1B3 in humans, ubiquitously expressed, and localized to the cytosol.{24381} The sGC histidine residue at position 105 is ligated to a ferrous heme that selectively binds NO to activate the C-terminal guanylate cyclase activity of the sGC heterodimer, catalyzing the synthesis of cGMP.{59045,59047} Knockdown of Gucy1B3 or expression of a heme-deficient sGC ?1 subunit inhibits NO-induced reductions in blood pressure and platelet activation in mice, indicating a heme-dependent role for the sGC ?1 subunit in blood pressure regulation.{59048} Cayman’s Guanylate Cyclase ?1 subunit (soluble) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the sGC ?1 subunit from human, bovine, and rat samples.