The human Mucin-1 antibody is reactive with 90% of breast carcinoma, most epithelial ovarian carcinoma and a high portion of the lung, urogenital and gastrointestinal carcinomas. Some reactivity is observed in the apical membrane of normal breast epithelium. Weak reactivity is also present in pancreas, kidney and lung. BC-2 reacts with a five amino acid epitope of the MUC-1 core protein which is less affective for glysosilation than most other MUC-1 epitopes. Localization: cytoplasm and membrane.
Positive control: Mamma carcinoma.