PAF Receptor (human) Polyclonal Antibody

PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling.{5109,5148,5150,5145,3513} Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain.{5150,5145} In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor.{4226} Human monocytes treated with INF-? have a 2-6 fold increase in PAF receptor expression compared to untreated cells.{4225} PAF receptor is detected on immunoblot at 48 kDa.{12339}