FFAR3 (GPR41) (C-Term) Polyclonal Antibody

GPR41 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).{25541,25605,25606} Several SCFAs have the potential to bind and activate GPR41, with pentanoate being the most potent agonist.{25605} GPR41 couples through the Pertussis toxin-sensitive Gi/o family and its expression has been described in adipose tissue and the colonic lumen.{25541,25605,25606} The activation of GPR41 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP.{25541,25605,25606} Activation of GPR41 may be involved in intestinal inflammation. The predicted size for GPR41 is 39 kDa. Cayman’s GPR41 (C-term) Polyclonal Antibody detects a 43 kDa band by western blot in cell lysates.