Phosphoramidon (sodium salt)

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases.{24074,24072} Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes.{24073,24074} It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 µM).{24082} Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.{24073}