BRD3 bromodomains 1 and 2 (human, recombinant)

Bromodomain-containing protein 3 (BRD3) is a member of the bromodomain and extra-terminal domain (BET) family.{19930} It is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple histone acetylation marks to the transcriptional regulation of target promoters, and an extra-terminal domain that mediates chromatin interactions. BRD3 is ubiquitously expressed and localizes to the nucleus where it preferentially binds acetylated histone H4 lysine 5 (H4K5), H4K12, and H4K14 at active transcription sites.{60983,19558} Knockdown of Brd3 enhances differentiation of C2C12 skeletal muscle myoblasts.{60984} Chromosomal translocations leading to the fusion of BRD3 with the nuclear protein in testis (NUT) gene and resulting in expression of BRD3-NUT fusion proteins are associated with NUT midline carcinoma (NMC).{60985} Cayman’s BRD3 bromodomains 1 and 2 protein can be used for Western blot (WB).