SUMO Polyclonal Antibody

The Small Ubiquitin Like Modifier (SUMO) protein is similar in structure and function to ubiquitin. However, SUMO does not typically target proteins for degradation as does ubiqutin. {14288,19512,19511,16072} SUMO is involved with the modification of a very diverse array of targets.{15532} Proteins involved with transcriptional regulation, DNA damage repair, genomic stability, nuclear transport, and histone modification are all subject to modification by SUMO.{19512,19513,15531,15532} SUMO typically functions by covalently binding to a target protein, followed by regulation of protein:protein and protein:DNA interactions.{19512} The SUMO family of proteins is highly conserved from yeast to human. Invertebrates contain a single SUMO gene (Smt3 in yeast and smo-1 in C. elegans), with three members of SUMO being identified in vertebrates to date (SUMO-1, SUMO-2 and SUMO-3).{21733}