Cyclophosphamide (hydrate)

Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders.{21842,21833} In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug since it is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.{22688,20436}