Ubiquitin Monoclonal Antibody (Clone 6C11-B3)

Ubiquitin is a regulatory protein encoded by three gene classes in humans, which code for fusion proteins between ubiquitin and zinc-finger proteins, ribosomal proteins, or ubiquitin repeats that are cleaved by esterases to release monomeric ubiquitin.{17707,17708} It is ubiquitously expressed and highly conserved among eukaryotic species. Ubiquitin is conjugated to misfolded, abnormal, short-lived, or foreign proteins by ubiquitin-conjugating enzymes (E2) and substrate-specific ubiquitin ligases (E3) to target them for degradation by the 26S proteasome or lysosome.{17707,26608} It is also conjugated to proteins to modify cell signaling through regulation of protein-protein interactions, activity, or subcellular localization.{26608} Dysregulation of ubiquitination has been implicated in the pathogenesis of neurodegenerative diseases, including Parkinson’s and Alzheimer’s diseases.{58819} Cayman’s Ubiquitin Monoclonal Antibody (Clone 6C11-B3) can be used for ELISA, immunocytochemistry (ICC), immunofluorescence (IF), and Western blot (WB) applications. The antibody recognizes ubiquitin at ~10 kDa from human samples.