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PARP (Cleaved) Monoclonal Antibody
13557-1
1 each
€793
Product description
The poly(ADP-ribose) polymerase (PARP) is involved in cell recovery from DNA damage, such as methylation of N3-adenine, which activates the base excision repair process. PARP is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. The 24 kDa fragment irreversibly binds to DNA and may contribute to the irreversibility of apoptosis by blocking the access of DNA repair enzymes to DNA strand breaks.
Specifications
Applications
FC, WB
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2b?
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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Productname
PARP (Cleaved) Monoclonal Antibody
13557-1
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PARP (Cleaved) Monoclonal Antibody
13557-1
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