HDAC11 Polyclonal Antibody

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the ?-amino groups of lysines located near the amino termini of core histone proteins.{17343} Eleven members of HDAC family have been identified in the past several years.{17241,17242} These HDAC family members are divided into two classes, I and II.The newest memeber of this family, HDAC11, has been cloned by Gao et al.{17240} HDAC11 transcripts were limited to kidney, heart, brain, skeletal muscle, and testis. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.