HDAC3 Polyclonal Antibody

Histone deacetylase 3 (HDAC3) is a zinc-dependent metalloenzyme and class I HDAC.{14468,60988} It is ubiquitously expressed and localizes primarily to the nucleus but also to the cytoplasm and plasma membrane. HDAC3 forms a complex with nuclear receptor co-repressor (NCOR) and silencing mediator of retinoic thyroid receptors (SMRT) to deacetylate histones and induce transcriptional repression and can be recruited to sites bound by activating transcription factor 2 (ATF2) without NCOR to induce inflammatory gene expression, indicating a role in transcriptional activation.{60988,60989} HDAC3 activity is correlated with various diseases, including cancer, metabolic disorders, autoimmune disorders, neurodegenerative and CNS disorders, and cardiovascular disease.{60990} Cayman’s HDAC3 Polyclonal Antibody can be used for chromatin immunoprecipitation (CHiP), immunoprecipitation (IP), and Western blot (WB) applications.