Cannabidiol dimethyl ether

Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{346} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{1462} CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 uM.{17111} It does not inhibit 5-LO effectively (IC50 >200 uM).{17111}