Myristic Acid Alkyne

Myristic acid is a 14-carbon saturated (14:0) fatty acid. In vivo, it is commonly added covalently to the N-terminus of proteins in a co-translational process termed N-myristoylation.{17231} The sirtuin SIRT6 removes this acyl group from myristoylated TNF-?, enhancing secretion.{22694} Myristic acid alkyne is a form of this myristic acid (Item No. 13351) with an ?-terminal alkyne. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.{17991,17992}