cis-trismethoxy Resveratrol

Resveratrol is a potent antioxidant found in grapes and red wine that also has anti-proliferative, anti-neoplastic and anti-angiogenic activities. In addition, resveratrol activates sirtuins{13296} and, in yeast, extends lifespan.{15280} cis-trismethoxy Resveratrol is a potent anti-mitotic drug that is 100-fold more active than resveratrol at inhibiting the growth of human colon cancer Caco-2 cells.{16948} It inhibits tubulin polymerization in a dose-dependent manner (IC50 = 4 ?M) and inhibits enzymes involved in the synthesis of the polyamines, putrescine, and spermidine.{16948,16950} trans-trismethoxy Resveratrol has superior pharmacokinetic characteristics when compared with resveratrol, including greater plasma exposure, longer elimination half-life, and lower clearance.{16949}