tetranor-PGDM

Prostaglandin D2 (PGD2; Item No. 12010) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as ?-trace.{328,1185} In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.{328,1185} Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.{580} tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine.{15162} The levels of tetranor-PGDM and 2,3-dinor-11?-PGF2? (Item No. 16530), a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.{15162}