SR 1555 (hydrochloride)

Retinoic acid receptor-related nuclear receptor ? (ROR?) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.{19869,19493} SR 1555 is a selective ligand of ROR? (IC50 = 1 ?M).{21696} It does not bind ROR?, LXR, or FXR. SR 1555 acts as an inverse agonist of ROR?, inhibiting endogenous IL-17A gene expression in mouse splenocytes and suppressing differentiation of TH17 cells when cultured under TH17 polarizing conditions.{21696} Moreover, SR 1555 stimulates T regulatory development when cultured under T regulatory polarizing conditions, unlike digoxin and ursolic acid.{21696}