CysLT2 Receptor (N-Term) Polyclonal Antibody

Cysteinyl leukotriene receptor 2 (CysLT2) is a G protein-coupled receptor that mediates the actions of leukotriene C4 (LTC4), LTD4, and, to a lesser extent, LTE4.{8519} It is expressed primarily in the heart, placenta, spleen, lymph nodes, and peripheral blood leukocytes.{8519,9059} Signaling induced by LTC4 through the CysLT2 receptor induces the production of chemokines via NF-?B and AP-1 activation in endothelial cells, indicating a role in inflammation.{61593} A CysLT2 receptor containing a leucine-to-glutamine substitution at position 129 (L129Q) has been found in human uveal melanoma cells and is associated with tumorigenesis in vivo.{61594,61595} SNPs in CYSLTR2 are associated with aspirin intolerance in patients with asthma.{61596} Cayman’s CysLT2 Receptor (N-Term) Polyclonal Antibody can be used for ELISA, flow cytometry (FC), and Western blot (WB) applications.