INK128

INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1 nM).{31895,21344,21346} It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2.{21344} INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors.{21344,21345} Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models.{21344} The effects of INK128 on gene expression also reduce invasion and metastasis.{20985}