(-)-Epicatechin

(-)-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities.{63044,23115,15205,23116,63045} It scavenges DPPH (Item No. 14805) radicals in a cell-free assay when used at a concentration of 5 µM.{23115} (-)-Epicatechin inhibits COX-1 (IC50 = 3.2 ?M).{50297} It acts synergistically with epigallocatechin gallate (Item No. 70935) to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 µM.{23116} (-)-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation.{63045}