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HMGB1 Monoclonal Antibody (Clone IMG19N10B7)
11512-1
1 each
€727
Product description
High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).{20300} It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.{20304}
Specifications
Applications
FC, IHC-P, WB
Host
Mouse
Clonality
Monoclonal
Clone
IMG19N10B7
Isotype
IgG2b?
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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Productname
HMGB1 Monoclonal Antibody (Clone IMG19N10B7)
11512-1
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Productname
HMGB1 Monoclonal Antibody (Clone IMG19N10B7)
11512-1
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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