Paxilline

Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM).{20615,20614} It also enhances the binding of charybdotoxin (Item No. 24115), a peptidyl neurotoxin, to BKCa channels.{20613} Paxilline is currently used to evaluate the role of BKCa channels in various cell processes and responses.{20612,20616}