DPY-30 (human recombinant)

DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.{20265} In C. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is required for proper growth and development.{20266,20267} DPY-30 is a homodimer in solution, and two monomers interact with one Ash2L monomer.{20268} Addition of DPY-30 to the MLL1, WDR5, RbBP5, and Ash2L complex results in a 2-fold increase in methylation rate, from 300x the MLL1 basal rate to 600x the MLL1 basal rate.{20269}