(+-)7(8)-EpDPA

Docosahexaenoic acid (DHA, Item No. 90310) is the most abundant w-3 fatty acid in neural tissues, especially in the brain and retina. (+-)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases.{29511} It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with w-3 fatty acids.{29249,29509} (+-)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting vasodilation, inhibiting angiogenesis, and decreasing inflammatory and neuropathic pain.{29509,26641,29512,29510} (+-)7(8)-EpDPA is a substrate of soluble epoxide hydrolase (KM = 15 µM), which converts it to the corresponding diol.{29509}