AdPLA2 Polyclonal Antibody

AdPLA2 is the first member of Group XVI phospholipase A2 (PLA2). The PLA2 superfamily consists of multiple enzymes that catalyze the hydrolysis of fatty acids from the sn-2 position in phospholipids. This pH- and calcium-dependent PL is highly expressed in adipose tissue and is associated with adipocyte differentiation and lipolysis. It has been implicated as a major player in the development of obesity.{16809,16829} Human AdPLA2 is a 162 amino acid protein with a calculated molecular weight of 18 kDa. It contains a transmembrane region and shares 70-75% sequence similarity with the mouse and rat proteins, respectively. Cayman’s antibody was raised against the C-terminal region of the human protein.