JMJD2D (human, recombinant)

Methylation of lysine residues in core histones plays a critical role in regulating gene expression.{18003} Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), leading to transcriptional repression and activation, respectively.{18004} Like other JmjC protein hydroxylase family members, JMJD2D is an ?-ketoglutarate-dependent Fe (II) oxygenase.{17970} Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.{18003}