OMDM-1

Numerous analogs of arachidonoyl ethanolamide (AEA, anandamide; Item No. 90050) potentiate its biological activity.{10254} This potentiation is ascribed either to inhibition of AEA reuptake into neurons or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.{10647} OMDM-1 is an endocannabinoid analog specifically designed to be a potent and selective inhibitor of the cellular uptake of AEA.{11240} Structurally, OMDM-1 is the amide of (S)-tyrosinol with oleic acid (Item No. 90260). In RBL-2H3 cells, OMDM-1 inhibits the cellular uptake of tritiated AEA with an IC50 of 2.4 µM, with negligible effects on the CB1 receptor and VR1.{11240}