13,14-dihydro-15-keto Prostaglandin D2-d4 (13,14-dihydro-15-keto PGD2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.{5248} It also inhibits ion flux in a canine colonic mucosa preparation.{9769} In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11?-hydroxy compounds which have also undergone ?-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.{418,35}
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13,14-dihydro-15-keto Prostaglandin D2-d4
10007978-25
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13,14-dihydro-15-keto Prostaglandin D2-d4
10007978-25
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