PTEN Blocking Peptide

To be used in conjunction with Cayman’s PTEN polyclonal antibody (Catalog No. 10005059) to block protein-antibody complex formation during immunochemical analysis of PTEN · PTEN dephosphorylates proteins and lipids such as AKT and phosphatidylinositol 3,4,5-triphosphate (PIP3) and therefore functions as a key regulatory enzyme in a central signal transduction pathway. PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.{13064} PTEN interacts with many other proteins to regulate cell division and migration as well as promoting apoptosis when necessary.{13065} Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma.{12235,13040}