QNZ

Nuclear factor-?B (NF-?B) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-?, IL-1?, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-?B activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-? production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.{12722}