CAY10486
Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.{10960,11758} CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 µM.{12441} It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM.{12441}
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