CAY10441

CAY10441 is an antagonist of the IP receptor.{11836} It is selective for the IP receptor over the prostaglandin E2 (PGE2) receptor subtypes EP1, EP2, EP3, and EP4, the FP and TP receptors, and a panel of 30 other receptors and ion channels but does bind to the ?2A-adrenergic and imidazoline I2 receptors. CAY10441 inhibits carbaprostacyclin-induced cAMP accumulation in SH-SY5Y cells (pKB = 8.8) and vasorelaxation of isolated human pulmonary arteries induced by the IP receptor agonist cicaprost (Item No. 16831; pA2 = 8.2).{11836,65532} It also decreases cicaprost-induced inhibition of platelet aggregation in human platelet-rich plasma.{65532} CAY10441 reduces acetic acid-induced writhing and carrageenan-induced paw hyperalgesia in rats (ED50s = 4 and 2.8 mg/kg, respectively).{11836}