Matairesinol

Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities.{57103,57104,57105,57106,57107} It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.{57103} Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml).{57104} It increases the lifespan of C. elegans when used at a concentration of 100 µM.{57105} Matairesinol (0.4, 2, and 10 µM) reduces neurotoxicity in neural PC12 cells induced by oxaliplatin (Item No. 13106).{57106} Topical administration of matairesinol (50 µg/ear) reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis.{57107}