(S)-Flurbiprofen

(S)-Flurbiprofen is the COX-active enantiomer of the non-selective COX inhibitor flurbiprofen (Item No. 70250) with IC50 values of 0.48 and 0.47 µM for COX-1 and COX-2, respectively, in guinea pig whole blood.{16202} It inhibits the release of 6-keto prostaglandin F1a (6-keto-PGF1a; Item No. 15210) and thromboxane B2 (TXB2; Item No. 19030) from rat whole blood, gastric mucosa, lung, and jejunal tissue ex vivo in a dose-dependent manner.{43119} (S)-Flurbiprofen (1 nM) inhibits basal and bradykinin-, serotonin-, and histamine-stimulated prostaglandin E2 (PGE2) release from isolated skin flaps of rat lower hind paws.{43120} It also inhibits release of the neuroinflammatory marker calcitonin gene-related peptide (CGRP; Item Nos. 24405 | 24725 | 24728) when used at a concentration of 1 ?M. In vivo, (S)-flurbiprofen reduces the number of flinches per minute in the formalin test in rats, indicating antinociceptive activity.{43121}