Optineurin (C-Term) Polyclonal Antibody

Optineurin, originally named FIP-2, is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as well as membrane traffic regulation and cellular morphogenesis. Optineurin protein is also involved in apoptosis, although the exact role is currently unknown. Increased apoptosis of trabecular meshwork cells is a factor in the pathogenesis of glaucoma and mutations in the optineurin gene have been correlated with the some types of the disease. Cayman Chemical is a leading provider of prostaglandin analogs, such as latanoprost and fluprostenol, currently utilized for lowering the intraocular pressure (IOP) associated with glaucoma. Our optineurin polyclonal antibody is another research tool useful for delineating the physiology of the disease.