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Monoclonal Antibody to TLR4 (Clone: HTA125)
10-3021
100 ug
€399
Legenda image
Intracellular flow analysis of hTLR4 antibody in Ramos Cell line using 2 µg/10^6 cells of hTLR4 antibody (Clone: HTA125). Green represents isotype control; red represents anti-hTLR4 antibody. Goat anti-mouse FITC conjugate was used as secondary antibody.
Product description
TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.
Specifications
Applications
FC
Host
Mouse
Clonality
Monoclonal
Clone
HTA125
Isotype
Mouse IgG2a, kappa
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C
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Monoclonal Antibody to TLR4 (Clone: HTA125)
10-3021
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Monoclonal Antibody to TLR4 (Clone: HTA125)
10-3021
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