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Monoclonal antibody to MyD88 (Clone: ABM2H20)
10-3012
100 ug
€399
Legenda image
Intracellular flow analysis of MyD88 in Jurkat using 0.5 µg/10^6 cells of MyD88 antibody (Clone: ABM2H20). Green represents isotype control; red represents anti-MyD88 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
Product description
MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.
Specifications
Applications
FC, WB
Host
Mouse
Clonality
Monoclonal
Clone
ABM2H20
Isotype
Mouse IgG1 Kappa
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C
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Monoclonal antibody to MyD88 (Clone: ABM2H20)
10-3012
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Monoclonal antibody to MyD88 (Clone: ABM2H20)
10-3012
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